Human Bradykinin Receptor B2 ELISA Kit | BDKRB2 elisa kit
Human Bradykinin Receptor B2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
BKR1: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily.
Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q32.1-q32.2
Cellular Component: neuron projection; integral to plasma membrane; endoplasmic reticulum; plasma membrane
Molecular Function: protein binding; bradykinin receptor activity; peptide binding
Biological Process: cell migration; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; response to mechanical stimulus; positive regulation of leukocyte migration; protein kinase C activation; response to lipopolysaccharide; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of blood pressure; negative regulation of cell growth; inflammatory response; sensory perception of pain
Research Articles on BDKRB2
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Product Notes
The Human BDKRB2 bdkrb1 (Catalog #AAA068311) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA068311 ELISA Kit recognizes Human BDKRB2. It is sometimes possible for the material contained within the vial of "Bradykinin Receptor B2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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