Mouse BCL2-like 1 ELISA Kit | BCL2L1 elisa kit

Mouse Bcl-2-like protein 1, BCL2L1 ELISA Kit

Cat. Num. AAA9323365

• Gene Names: Bcl2l1; BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
• Reactivity: Mouse
• Synonyms: BCL2-like 1; Mouse Bcl-2-like protein 1; BCL2L1 ELISA Kit; Mouse Bcl-2-like protein 1 (BCL2L1) ELISA kit; BCL-XL/S; BCL2L; BCLX; Bcl-X; DKFZp781P2092; bcl-xL; bcl-xS; OTTHUMP00000030550; BCL2L1 elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples.
• Assay Type: Sandwich (Quantitative)
• Detection Range: 0.625ng/ml-20ng/ml.
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for BCL2L1 elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of BCL2L1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 577019442
• NCBI GeneID: 12048
• NCBI Accession #: NP_001276645.1
• NCBI GenBank Nucleotide #: NM_001289716.1
• UniProt Accession #: Q64373; O35844; Q60657; Q60658; Q61338
• Molecular Weight: 26,132 Da
• NCBI Official Full Name: bcl-2-like protein 1 isoform a
• NCBI Official Synonym Full Names: BCL2-like 1
• NCBI Official Symbol: Bcl2l1
• NCBI Official Synonym Symbols: BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
• NCBI Protein Information: bcl-2-like protein 1; apoptosis regulator Bcl-X; B-cell leukemia/lymphoma x; anti-apoptosis regulatory protein
• UniProt Protein Name: Bcl-2-like protein 1
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: Bcl2l1
• UniProt Synonym Gene Names: Bcl2l; Bclx; Bcl2-L-1
• UniProt Entry Name: B2CL1_MOUSE

NCBI Description

This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Uniprot Description

Bcl-xL: an antiapoptotic member of the Bcl-2 family. Located at the outer mitochondrial membrane and regulates outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are potent inducers of cell apoptosis. Two alternatively spliced isoforms have been reported.

Protein type: Membrane protein, integral; Apoptosis; Mitochondrial; Autophagy

Cellular Component: mitochondrial envelope; centrosome; mitochondrion; integral to membrane; cytosol; mitochondrial outer membrane; cytoskeleton; membrane; mitochondrial membrane; cytoplasm; mitochondrial inner membrane; nucleolus; synapse; cytoplasmic vesicle; intracellular; nucleus; cell junction

Molecular Function: identical protein binding; BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity; caspase inhibitor activity; BH3 domain binding; protein kinase binding

Biological Process: positive regulation of apoptosis; apoptosis; cytokinesis; negative regulation of caspase activity; cellular process regulating host cell cycle in response to virus; germ cell development; regulation of apoptosis; response to radiation; ovarian follicle development; regulation of mitochondrial membrane potential; positive regulation of cell proliferation; negative regulation of neuron apoptosis; release of cytochrome c from mitochondria; in utero embryonic development; response to virus; mitotic cell cycle checkpoint; suppression by virus of host apoptosis; male gonad development; cell proliferation; neuron apoptosis; fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; response to cycloheximide; spermatogenesis; regulation of mitochondrial membrane permeability; negative regulation of apoptosis; growth