Large proline-rich protein BAG6 (BAG6), partial Recombinant Protein | BAG6 recombinant protein

Recombinant Ornithorhynchus anatinus Large proline-rich protein BAG6 (BAG6), partial

• Gene Names: BAG6; BAT3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Large proline-rich protein BAG6 (BAG6); partial; Recombinant Ornithorhynchus anatinus Large proline-rich protein BAG6 (BAG6); Large proline-rich protein BAG6; BCL2-associated athanogene 6; HLA-B-associated transcript 3; BAG6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)

• Species: Ornithorhynchus anatinus (Duckbill platypus)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 337298972
• NCBI GeneID: 100529065
• NCBI Accession #: NP_001229675.1
• NCBI GenBank Nucleotide #: NM_001242746.1
• UniProt Accession #: A7X5R6
• Molecular Weight: 112,586 Da
• NCBI Official Full Name: large proline-rich protein BAG6
• NCBI Official Symbol: BAG6
• NCBI Official Synonym Symbols: BAT3
• NCBI Protein Information: large proline-rich protein BAG6; HLA-B-associated transcript 3; large proline-rich protein BAT3
• UniProt Protein Name: Large proline-rich protein BAG6
• Protein Family: Large proline-rich protein
• UniProt Gene Name: BAG6
• UniProt Synonym Gene Names: BAT3
• UniProt Entry Name: BAG6_ORNAN

Uniprot Description

Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Moreover, it regulates the stability and the degradation of proteins by the proteasome. For instance, it is required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. It is also involved in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol. Binds the mislocalized proteins, preventing their aggregation in the cytosol, and promotes their ubiquitination. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2.