Bile acid-CoA:amino acid N-acyltransferase (BAAT) Recombinant Protein | BAAT recombinant protein

Recombinant Human Bile acid-CoA:amino acid N-acyltransferase (BAAT)

Cat. Num. AAA1437262

• Gene Names: BAAT; BAT; BACAT
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bile acid-CoA:amino acid N-acyltransferase (BAAT); Recombinant Human Bile acid-CoA:amino acid N-acyltransferase (BAAT); BAAT recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-418, Full length protein
• Sequence: MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDLNHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVASAPKASLTLERWYVAPGVTRIKVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRASLLASRGFASLALAYHNYEDLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQIGLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFETTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKNNWTLLSYPGAGHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVTSQL
• Sequence Length: 418

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for BAAT recombinant protein

This protein is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 189083866
• NCBI GeneID: 570
• NCBI Accession #: NP_001121082.1
• NCBI GenBank Nucleotide #: NM_001127610.1
• UniProt Accession #: Q14032; Q3B7W9; Q96L31
• Molecular Weight: 46,299 Da
• NCBI Official Full Name: bile acid-CoA:amino acid N-acyltransferase
• NCBI Official Synonym Full Names: bile acid-CoA:amino acid N-acyltransferase
• NCBI Official Symbol: BAAT
• NCBI Official Synonym Symbols: BAT; BACAT
• NCBI Protein Information: bile acid-CoA:amino acid N-acyltransferase
• UniProt Protein Name: Bile acid-CoA:amino acid N-acyltransferase
• Protein Family: Bile acid-CoA:amino acid N-acyltransferase
• UniProt Gene Name: BAAT
• UniProt Synonym Gene Names: BAT

NCBI Description

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.