FcRn/FCGRT & B2M Heterodimer Recombinant Protein | B2M recombinant protein

Recombinant Cynomolgus FcRn/FCGRT & B2M Heterodimer Protein (C-DYKDDDDK,C-His)

Cat. Num. AAA2557567

• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: FcRn/FCGRT & B2M Heterodimer; Recombinant Cynomolgus FcRn/FCGRT & B2M Heterodimer Protein (C-DYKDDDDK; C-His); Beta-2-Microglobulin; B2M; B2M recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Ile21-Met119 & Ala24-Ser297
• Sequence Length: 119

• Species: Cynomolgus
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-DYKDDDDK,C-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for B2M recombinant protein

Protein Construction: Recombinant Cynomolgus FCGRT & B2M Heterodimer is produced by our mammalian expression system and the target gene encoding Ile21-Met119&Ala24-Ser297 is expressedwith a DYKDDDDK tag at the C-terminus, 6His tag at the C-terminus.

Background: beta-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

NCBI and Uniprot Product Information

• NCBI GI #: 31339986
• NCBI GeneID: 101867173
• UniProt Accession #: Q8SPW0; Q8SPV9
• Molecular Weight: Molecular Mass: 12.6 & 31.3kDa; Actual Protein Molecular Mass: 14 & 33kDa
• NCBI Official Full Name: Beta-2-microglobulin
• NCBI Official Symbol: B2M
• NCBI Protein Information: beta-2-microglobulin
• UniProt Protein Name: Beta-2-microglobulin
• Protein Family: Beta-2-microglobulin
• UniProt Gene Name: B2M

Uniprot Description

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system ().