Typical Testing Data/Standard Curve (for reference only)
Human Vasopressin-neurophysin 2-copeptin ELISA Kit | AVP elisa kit
Human Vasopressin-neurophysin 2-copeptin ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]
Uniprot Description
AVP: Neurophysin 2 specifically binds vasopressin. Defects in AVP are the cause of diabetes insipidus, neurohypophyseal (NDI). A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopression deficiency during childhood. Belongs to the vasopressin/oxytocin family.
Protein type: Hormone; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20p13
Cellular Component: cytosol; dendrite; extracellular region; extracellular space; secretory granule
Molecular Function: caspase inhibitor activity; neurohypophyseal hormone activity; neuropeptide hormone activity; protein kinase activity; receptor binding; signal transducer activity; V1A vasopressin receptor binding; V1B vasopressin receptor binding
Biological Process: cell-cell signaling; circadian rhythm; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; grooming behavior; hyperosmotic salinity response; locomotory behavior; maternal behavior; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; positive regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; renal water homeostasis; response to ethanol; response to nicotine; response to testosterone stimulus; signal transduction; social behavior; sodium-independent organic anion transport; transmembrane transport; vasoconstriction; water transport
Disease: Diabetes Insipidus, Neurohypophyseal
Research Articles on AVP
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Product Notes
The Human AVP avp (Catalog #AAA2880180) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880180 ELISA Kit recognizes Human AVP. It is sometimes possible for the material contained within the vial of "Vasopressin-neurophysin 2-copeptin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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