Human ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c ELISA Kit | ATP6V0C elisa kit

Human V-type proton ATPase 16 kDa proteolipid subunit, ATP6V0C ELISA Kit

Cat. Num. AAA9329169

• Gene Names: ATP6V0C; ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal 16kDa; V0 subunit c; Human V-type proton ATPase 16 kDa proteolipid subunit; ATP6V0C ELISA Kit; Human V-type proton ATPase 16 kDa proteolipid subunit (ATP6V0C) ELISA kit; ATP6C; ATP6L; ATPL; VATL; Vma3; lysosomal; H (+) -transporting two-sector ATPase; 16 kDa subunit; V-ATPase subunit c; vacuolar ATP synthase 16 kDa proteolipid subun; ATP6V0C elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%)is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for ATP6V0C elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of ATP6V0C (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 310832382
• NCBI GeneID: 527
• NCBI Accession #: NP_001185498.1
• NCBI GenBank Nucleotide #: NM_001198569.1
• UniProt Accession #: P27449; Q6FH26
• Molecular Weight: 15,736 Da
• NCBI Official Full Name: V-type proton ATPase 16 kDa proteolipid subunit
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
• NCBI Official Symbol: ATP6V0C
• NCBI Official Synonym Symbols: ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L
• NCBI Protein Information: V-type proton ATPase 16 kDa proteolipid subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar H+ ATPase proton channel subunit; vacuolar proton pump 16 kDa proteolipid subunit; vacuolar ATP synthase 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit
• UniProt Protein Name: V-type proton ATPase 16 kDa proteolipid subunit
• UniProt Gene Name: ATP6V0C
• UniProt Synonym Gene Names: ATP6C; ATP6L; ATPL; V-ATPase 16 kDa proteolipid subunit
• UniProt Entry Name: VATL_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Uniprot Description

ATP6V0C: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase proteolipid subunit family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel; Transporter, iron; Transporter

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: phagocytic vesicle membrane; focal adhesion; lysosomal membrane; integral to membrane; endosome membrane

Molecular Function: protein binding; ubiquitin protein ligase binding; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism

Biological Process: interaction with host; proton transport; viral reproduction; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport; positive regulation of Wnt receptor signaling pathway