Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2) Recombinant Protein | Atp2a2 recombinant protein
Recombinant Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2) , partial
Gene Names
Atp2a2; Serca2; SercaII
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2); Recombinant Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2); partial; Atp2a2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
314-756. Partial, provide one of the complete cytoplasmic domains.
Sequence
VITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNM
Sequence Length
756
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
109,681 Da
NCBI Official Full Name
sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
NCBI Official Synonym Full Names
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
NCBI Official Symbol
Atp2a2
NCBI Official Synonym Symbols
Serca2; SercaII
NCBI Protein Information
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
UniProt Protein Name
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Protein Family
UniProt Gene Name
Atp2a2
UniProt Synonym Gene Names
SERCA2; SR Ca(2+)-ATPase 2
NCBI Description
sarco(endo)plasmic reticulum Ca(2+) ATPase; involved in calcium transport and cycling in the heart and in calcium sequestering in enamel forming cells [RGD, Feb 2006]
Uniprot Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation.
Research Articles on Atp2a2
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Product Notes
The Atp2a2 atp2a2 (Catalog #AAA1040471) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 314-756. Partial, provide one of the complete cytoplasmic domains. The amino acid sequence is listed below: VITTCLALGT RRMAKKNAIV RSLPSVETLG CTSVICSDKT GTLTTNQMSV CRMFILDKVE GDTCSLNEFT ITGSTYAPIG EVQKDDKPVK CHQYDGLVEL ATICALCNDS ALDYNEAKGV YEKVGEATET ALTCLVEKMN VFDTELKGLS KIERANACNS VIKQLMKKEF TLEFSRDRKS MSVYCTPNKP SRTSMSKMFV KGAPEGVIDR CTHIRVGSTK VPMTPGVKQK IMSVIREWGS GSDTLRCLAL ATHDNPLRRE EMHLEDSANF IKYETNLTFV GCVGMLDPPR IEVASSVKLC RQAGIRVIMI TGDNKGTAVA ICRRIGIFGQ DEDVTSKAFT GREFDELSPS AQRDACLNAR CFARVEPSHK SKIVEFLQSF DEITAMTGDG VNDAPALKKS EIGIAMGSGT AVAKTASEMV LADDNFSTIV AAVEEGRAIY NNM . It is sometimes possible for the material contained within the vial of "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (Atp2a2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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