Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), partial Recombinant Protein | ATP1A1 recombinant protein
Recombinant Human Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), partial
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Description
ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described.
Protein type: Hydrolase; EC 3.6.3.9; Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: Golgi apparatus; protein complex; basolateral plasma membrane; endoplasmic reticulum; T-tubule; integral to membrane; caveola; membrane; apical plasma membrane; melanosome; plasma membrane; sodium:potassium-exchanging ATPase complex; endosome; vesicle; sarcolemma
Molecular Function: potassium ion binding; protein domain specific binding; protein binding; sodium ion binding; chaperone binding; phosphoric monoester hydrolase activity; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding
Biological Process: response to drug; cellular sodium ion homeostasis; negative regulation of heart contraction; membrane hyperpolarization; positive regulation of striated muscle contraction; regulation of sodium ion transport; cellular potassium ion homeostasis; negative regulation of glucocorticoid biosynthetic process; potassium ion import; dephosphorylation; regulation of blood pressure; transmembrane transport; positive regulation of heart contraction; regulation of the force of heart contraction; cardiac muscle contraction
Research Articles on ATP1A1
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Product Notes
The ATP1A1 atp1a1 (Catalog #AAA951051) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 339-772. Partial. The amino acid sequence is listed below: TVTVCLTLTA KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH EADTTENQSG VSFDKTSATW LALSRIAGLC NRAVFQANQE NLPILKRAVA GDASESALLK CIELCCGSVK EMRERYAKIV EIPFNSTNKY QLSIHKNPNT SEPQHLLVMK GAPERILDRC SSILLHGKEQ PLDEELKDAF QNAYLELGGL GERVLGFCHL FLPDEQFPEG FQFDTDDVNF PIDNLCFVGL ISMIDPPRAA VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL NIPVSQVNPR DAKACVVHGS DLKDMTSEQL DDILKYHTEI VFARTSPQQK LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGVAMGIAG SDVSKQAADM ILLDDNFASI VTGVEEGRLI FDNL . It is sometimes possible for the material contained within the vial of "Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), partial, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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