ACCN3 Blocking Peptide | ASIC3 blocking peptide

ACCN3 Antibody (N-term) Blocking Peptide

• Gene Names: ASIC3; ACCN3; TNaC1; DRASIC; SLNAC1
• Synonyms: ACCN3; ACCN3 Antibody (N-term) Blocking Peptide; Acid-sensing ion channel 3; ASIC3; hASIC3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; Testis sodium channel 1; hTNaC1; SLNAC1; TNAC1; ASIC3 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 531

• Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity).
• Tissue Location: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ASIC3 blocking peptide

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

NCBI and Uniprot Product Information

• NCBI GI #: 82582992
• NCBI GeneID: 9311
• UniProt Accession #: Q9UHC3; O60263; O75906; Q59FN9; Q9UER8; Q9UHC4; B2R9V0
• Molecular Weight: 44,999 Da
• NCBI Official Full Name: Acid-sensing ion channel 3
• NCBI Official Synonym Full Names: acid sensing ion channel subunit 3
• NCBI Official Symbol: ASIC3
• NCBI Official Synonym Symbols: ACCN3; TNaC1; DRASIC; SLNAC1
• NCBI Protein Information: acid-sensing ion channel 3
• UniProt Protein Name: Acid-sensing ion channel 3
• Protein Family: Acid-sensing ion channel
• UniProt Gene Name: ASIC3
• UniProt Synonym Gene Names: ACCN3; SLNAC1; TNAC1; ASIC3; hASIC3; hTNaC1
• UniProt Entry Name: ASIC3_HUMAN

NCBI Description

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Uniprot Description

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.