Western Blot (WB)
(Anti-ASIC3 antibody, MBS176183, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Testis Tissue LysateLane 3: U87 Cell LysateLane 4: NEURO Cell LysateLane 5: SMMC Cell Lysate )
Rabbit ASIC3 Polyclonal Antibody | anti-ASIC3 antibody
Anti-ASIC3 antibody
Western Blot (WB)
(Anti-ASIC3 antibody, MBS176183, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Testis Tissue LysateLane 3: U87 Cell LysateLane 4: NEURO Cell LysateLane 5: SMMC Cell Lysate )
Western Blot (WB)
(Anti-ASIC3 antibody, MBS176183, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Testis Tissue LysateLane 3: U87 Cell LysateLane 4: NEURO Cell LysateLane 5: SMMC Cell Lysate )
Background: ASIC3(Acid-Sensing Ion Channel3), also known as TESTIS SODIUM CHANNEL 1(TNAC1) or DORSAL ROOT ACID-SENSING ION CHANNEL(DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the ACCN3 gene to chromosome 7q35. De Weille et al.(1998) found that human ASIC3 supported an H(+)-gated cation current in COS cells with kinetics similar to those of rat Asic3. Babinski et al.(1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Uniprot Description
ASIC3: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, integral; Channel, cation; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; enterobactin transporter activity; cation channel activity; sodium channel activity; PDZ domain binding
Biological Process: detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; transport; response to heat; sensory perception; sensory perception of sour taste; enterobactin transport; response to acidity; detection of temperature stimulus involved in sensory perception of pain; signal transduction; transmembrane transport
Research Articles on ASIC3
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Product Notes
The ASIC3 asic3 (Catalog #AAA176183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ASIC3 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ASIC3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ASIC3 asic3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ASIC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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