Asialoglycoprotein Receptor 1 Recombinant Protein | ASGR1 recombinant protein

Recombinant Human Asialoglycoprotein Receptor 1 Protein

Cat. Num. AAA2556700

• Gene Names: ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Asialoglycoprotein Receptor 1; Recombinant Human Asialoglycoprotein Receptor 1 Protein; ASGP-R 1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; Hepatic Lectin H1; HL-1; ASGR1; CLEC4H1; ASGR1 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Length: 252

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Gln62-Ile291
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for ASGR1 recombinant protein

Protein Construction: Recombinant Human Asialoglycoprotein Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln62-Ile291 is expressed with a 6His tag at the C-terminus.

Background: Asialoglycoprotein Receptor 1 (ASGPR1) is an endocytic recycling receptor, belongs to the long-form subfamily of the C-type/Ca2+-dependent lectin family. ASGPR consists of two noncovalently-linked subnits, ASGPR1 and ASGPR2. ASGPR1 mediates the endocytosis of plasma glycoproteins, recognizes terminal galactose and N-acetylgalactosamine units. When the ligand binds to to ASGPR1, results in the complex is internalized and transported to a sorting organelle, then ASGPR1 and ligand can be disassociated, ASGPR1 returns to the cell membrane surface.

NCBI and Uniprot Product Information

• NCBI GI #: 308387363
• NCBI GeneID: 432
• NCBI Accession #: NP_001184145.1
• NCBI GenBank Nucleotide #: NM_001197216.2
• UniProt Accession #: P07306; I3L1X1
• Molecular Weight: Molecular Mass: 27.4kDa; Actual Protein Molecular Mass: 38kDa
• NCBI Official Full Name: asialoglycoprotein receptor 1 isoform b
• NCBI Official Synonym Full Names: asialoglycoprotein receptor 1
• NCBI Official Symbol: ASGR1
• NCBI Official Synonym Symbols: HL-1; ASGPR; ASGPR1; CLEC4H1
• NCBI Protein Information: asialoglycoprotein receptor 1
• UniProt Protein Name: Asialoglycoprotein receptor 1
• Protein Family: Asialoglycoprotein receptor
• UniProt Gene Name: ASGR1
• UniProt Synonym Gene Names: CLEC4H1; ASGP-R 1; ASGPR 1; HL-1

NCBI Description

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.