Histone chaperone ASF1A (ASF1A) Recombinant Protein | ASF1A recombinant protein

Recombinant Human Histone chaperone ASF1A (ASF1A)

Cat. Num. AAA1392039

• Gene Names: ASF1A; CIA; CGI-98; HSPC146
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Histone chaperone ASF1A (ASF1A); Recombinant Human Histone chaperone ASF1A (ASF1A); Histone chaperone ASF1A; Anti-silencing function protein 1 homolog A; hAsf1; hAsf1a; CCG1-interacting factor A; CIA; hCIA; ASF1A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-204aa; Full Length
• Sequence: MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM
• Sequence Length: 204

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for ASF1A recombinant protein

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Product Categories/Family for ASF1A recombinant protein

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 7661592
• NCBI GeneID: 25842
• NCBI Accession #: NP_054753.1
• NCBI GenBank Nucleotide #: NM_014034.2
• UniProt Accession #: Q9Y294; Q6IA08; Q9P014
• Molecular Weight: 50 kDa
• NCBI Official Full Name: histone chaperone ASF1A
• NCBI Official Synonym Full Names: anti-silencing function 1A histone chaperone
• NCBI Official Symbol: ASF1A
• NCBI Official Synonym Symbols: CIA; CGI-98; HSPC146
• NCBI Protein Information: histone chaperone ASF1A; hCIA; hAsf1; hAsf1a; CCG1-interacting factor A; ASF1 anti-silencing function 1 homolog A; anti-silencing function protein 1 homolog A
• UniProt Protein Name: Histone chaperone ASF1A
• Protein Family: Histone chaperone
• UniProt Gene Name: ASF1A
• UniProt Synonym Gene Names: hAsf1; hAsf1a; CIA; hCIA
• UniProt Entry Name: ASF1A_HUMAN

NCBI Description

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]

Uniprot Description

ASF1A: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family.

Protein type: DNA repair, damage; Histone-binding

Chromosomal Location of Human Ortholog: 6q22.31

Cellular Component: nucleoplasm; protein complex; nuclear chromatin; nucleus

Molecular Function: protein binding; histone binding; chromatin binding

Biological Process: osteoblast differentiation; nucleosome assembly; muscle cell differentiation; DNA replication-independent nucleosome assembly; negative regulation of chromatin silencing; transcription, DNA-dependent; chromatin modification; DNA repair; DNA replication-dependent nucleosome assembly