AS3MT recombinant protein

Recombinant AS3MT protein

Cat. Num. AAA389436

• Gene Names: AS3MT; CYT19
• Synonyms: AS3MT; Recombinant AS3MT protein; Arsenite Methyltransferase; Methylarsonite Methyltransferase; AS3MT recombinant protein

• Host: E Coli
• Form/Format: Recombinant AS3MT protein is supplied in 25mM Tris pH8.0, 300mM NaCl, 10% glycerol, 0.5mM TCEP.

• Protein Species: Human
• Tag: His-Tag
• Protein Details: Recombinant AS3MT protein was expressed in E Coli as the full length protein (accession number NP_065733.2) with an N-terminal 6×His-tag.
• Notes: This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data this product is shown.
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.; Shipping Temp: Dry Ice

SDS-Page

(Recombinant AS3MT protein 12.5% SDS-PAGE Coomassie staining M.W.: 43.68 kDa Purity: ? 90%)

Related Product Information for AS3MT recombinant protein

Background: Methylarsonite methyltransferase is also known as AS3MT,and the main function of AS3MT is catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals.It methylates arsenite to form methylarsonate, Me-AsO3H2, which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2.Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me2As(O)-OH.

Product Categories/Family for AS3MT recombinant protein

Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 109389364
• NCBI GeneID: 57412
• NCBI Accession #: NP_065733.2
• NCBI GenBank Nucleotide #: NM_020682.3
• UniProt Accession #: Q9HBK9; Q0VDK3; Q0VDK4; Q5PZ02; A6NP79
• Molecular Weight: 31,098 Da
• NCBI Official Full Name: arsenite methyltransferase
• NCBI Official Synonym Full Names: arsenite methyltransferase
• NCBI Official Symbol: AS3MT
• NCBI Official Synonym Symbols: CYT19
• NCBI Protein Information: arsenite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; arsenic (+3 oxidation state) methyltransferase; methylarsonite methyltransferase; methyltransferase cyt19
• UniProt Protein Name: Arsenite methyltransferase
• Protein Family: Arsenite methyltransferase
• UniProt Gene Name: AS3MT
• UniProt Synonym Gene Names: CYT19
• UniProt Entry Name: AS3MT_HUMAN

NCBI Description

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

Uniprot Description

AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.

Protein type: Methyltransferase; Mitochondrial; EC 2.1.1.137

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity

Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process