Mouse aryl hydrocarbon receptor nuclear translocator-like ELISA Kit | ARNTL elisa kit
Mouse Aryl hydrocarbon receptor nuclear transloCator-like protein 1, ARNTL ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
Uniprot Description
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: Transcription factor; DNA-binding
Cellular Component: nuclear body; transcription factor complex; cytoplasm; nucleus
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; DNA binding; aryl hydrocarbon receptor binding; protein heterodimerization activity; sequence-specific DNA binding; bHLH transcription factor binding; Hsp90 protein binding; transcription factor binding; transcription factor activity
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription, DNA-dependent; rhythmic process; response to redox state; positive regulation of circadian rhythm; signal transduction; negative regulation of fat cell differentiation; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; regulation of protein catabolic process; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; regulation of hair cycle
Research Articles on ARNTL
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Product Notes
The Mouse ARNTL arntl (Catalog #AAA9328769) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328769 ELISA Kit recognizes Mouse ARNTL. It is sometimes possible for the material contained within the vial of "aryl hydrocarbon receptor nuclear translocator-like, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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