Pigeon Rho Guanine Nucleotide Exchange Factor 7 ELISA Kit | ARHGEF7 elisa kit

Pigeon Rho Guanine Nucleotide Exchange Factor 7 ELISA Kit

• Gene Names: ARHGEF7; P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
• Reactivity: Pigeon
• Synonyms: Rho Guanine Nucleotide Exchange Factor 7; Pigeon Rho Guanine Nucleotide Exchange Factor 7 ELISA Kit; ARHGEF7 elisa kit

• Reactivity: Pigeon
• Sequence Length: 646

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 166064038
• NCBI GeneID: 8874
• NCBI Accession #: NP_001106985.1
• NCBI GenBank Nucleotide #: NM_001113513.1
• UniProt Accession #: Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1; B1ALK6; B1ALK8
• Molecular Weight: 90,012 Da
• NCBI Official Full Name: rho guanine nucleotide exchange factor 7 isoform a
• NCBI Official Synonym Full Names: Rho guanine nucleotide exchange factor (GEF) 7
• NCBI Official Symbol: ARHGEF7
• NCBI Official Synonym Symbols: P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314
• NCBI Protein Information: rho guanine nucleotide exchange factor 7; PAK-interacting exchange factor beta; SH3 domain-containing proline-rich protein
• UniProt Protein Name: Rho guanine nucleotide exchange factor 7
• Protein Family: Rho guanine nucleotide exchange factor
• UniProt Gene Name: ARHGEF7
• UniProt Synonym Gene Names: COOL1; KIAA0142; P85SPR; PAK3BP; PIXB
• UniProt Entry Name: ARHG7_HUMAN

NCBI Description

Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ARHGEF7: a RAC1 guanine nucleotide exchange factor (GEF). Can induce membrane ruffling. Interacts with PAK kinases through its SH3 domain. Acts both as an activator and a downstream target for Cdc42. Its EGF-dependent phosphorylation activates its nucleotide exchange factor for Cdc42 and regulates its interaction with the E3 ligase Cbl, thus modulating Cbl-catalysed EGFR degradation. Its phosphorylation status is necessary to maintain the balance between normal signaling by EGFR and Src versus aberrant growth and transformation. Four alternatively spliced isoforms have been described.

Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: ruffle; neuron projection; protein complex; focal adhesion; cell soma; lamellipodium; cell cortex; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; protein kinase binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; lamellipodium biogenesis; focal adhesion formation; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; hemopoietic progenitor cell differentiation; positive regulation of GTPase activity