Rho guanine nucleotide exchange factor 18 (ARHGEF18) Recombinant Protein | ARHGEF18 recombinant protein

Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18) , partial

• Gene Names: ARHGEF18; RP78; P114-RhoGEF
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Rho guanine nucleotide exchange factor 18 (ARHGEF18); Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18); partial; ARHGEF18 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,015

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ARHGEF18 recombinant protein

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). This protein is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 195972857
• NCBI GeneID: 23370
• NCBI Accession #: NP_001124427.1
• NCBI GenBank Nucleotide #: NM_001130955.1
• UniProt Accession #: Q6ZSZ5; O60274; Q6DD92; A8MV62; B5ME81
• Molecular Weight: 114,077 Da
• NCBI Official Full Name: rho guanine nucleotide exchange factor 18 isoform b
• NCBI Official Synonym Full Names: Rho/Rac guanine nucleotide exchange factor 18
• NCBI Official Symbol: ARHGEF18
• NCBI Official Synonym Symbols: RP78; P114-RhoGEF
• NCBI Protein Information: rho guanine nucleotide exchange factor 18
• UniProt Protein Name: Rho guanine nucleotide exchange factor 18
• Protein Family: Rho guanine nucleotide exchange factor
• UniProt Gene Name: ARHGEF18
• UniProt Synonym Gene Names: KIAA0521; p114-Rho-GEF; p114RhoGEF; SA-RhoGEF

NCBI Description

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Uniprot Description

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950).