Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) Recombinant Protein | ARFGEF2 recombinant protein

Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) , partial

• Gene Names: ARFGEF2; BIG2; PVNH2; dJ1164I10.1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2); Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2); partial; ARFGEF2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,785

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ARFGEF2 recombinant protein

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. This protein is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.

NCBI and Uniprot Product Information

• NCBI GI #: 150417986
• NCBI GeneID: 10564
• NCBI Accession #: NP_006411.2
• NCBI GenBank Nucleotide #: NM_006420.2
• UniProt Accession #: Q9Y6D5; Q5TFT9; Q9NTS1
• Molecular Weight: 202,038 Da
• NCBI Official Full Name: brefeldin A-inhibited guanine nucleotide-exchange protein 2
• NCBI Official Synonym Full Names: ADP ribosylation factor guanine nucleotide exchange factor 2
• NCBI Official Symbol: ARFGEF2
• NCBI Official Synonym Symbols: BIG2; PVNH2; dJ1164I10.1
• NCBI Protein Information: brefeldin A-inhibited guanine nucleotide-exchange protein 2
• UniProt Protein Name: Brefeldin A-inhibited guanine nucleotide-exchange protein 2
• UniProt Gene Name: ARFGEF2
• UniProt Synonym Gene Names: ARFGEP2; BIG2; Brefeldin A-inhibited GEP 2

NCBI Description

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Uniprot Description

Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.