Human ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) ELISA Kit | ARFGEF1 elisa kit
Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1, ARFGEF1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Uniprot Description
ARFGEF1: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.
Protein type: GEFs; Nucleolus; GEFs, ARF
Chromosomal Location of Human Ortholog: 8q13
Cellular Component: small nuclear ribonucleoprotein complex; Golgi membrane; nucleoplasm; Golgi apparatus; nuclear matrix; perinuclear region of cytoplasm; cytoplasm; nucleolus; trans-Golgi network; cytosol
Molecular Function: protein binding; myosin binding; guanyl-nucleotide exchange factor activity; ARF guanyl-nucleotide exchange factor activity
Biological Process: vesicle-mediated transport; protein transport; exocytosis; negative regulation of actin filament polymerization; endomembrane organization; regulation of ARF protein signal transduction; Golgi organization and biogenesis; positive regulation of GTPase activity
Research Articles on ARFGEF1
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Product Notes
The Human ARFGEF1 arfgef1 (Catalog #AAA9326340) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326340 ELISA Kit recognizes Human ARFGEF1. It is sometimes possible for the material contained within the vial of "ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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