Apolipoprotein-D Recombinant Protein | APOD recombinant protein

Recombinant Human Apolipoprotein-D, HEK

Cat. Num. AAA146323

• Purity: Purity as determined by densitometric image analysis is greater than 95%.
• Synonyms: Apolipoprotein-D; Recombinant Human Apolipoprotein-D; HEK; APOD Human; Apolipoprotein-D Human Recombinant; Apolipoprotein D; Apo-D; ApoD; APOD; APOD recombinant protein

• Host: HEK 293
• Purity/Purification: Purity as determined by densitometric image analysis is greater than 95%.
• Form/Format: Filtered (0.4 um) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.; Filtered White lyophilized (freeze-dried) powder.
• Sequence: QAFHLGKCPN PPVQENFDVN KYLGRWYEIE KIPTTFENGR CIQANYSLME NGKIKVLNQE LRADGTVNQI EGEATPVNLT EPAKLEVKFS WFMPSAPYWI LATDYENYAL VYSCTCIIQL FHVDFAWILA RNPNLPPETV DSLKNILTSN NIDVKKMTVT DQVNCPKLSH HHHHH
• Sequence Length: 189

• Solubility: It is recommended to add 200 ul deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time.

Related Product Information for APOD recombinant protein

Description: Apolipoprotein-D Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (aa 21-189) containing a total of 175 amino acids, having a molecular mass of 20.1kDa (calculated) and fused to a 6 aa His tag at C-Terminus.The Human APOD is purified by proprietary chromatographic techniques.

Introduction: Apolipoprotein-D is mainly associated with high density lipoproteins in human plasma. Apolipoprotein-D is an atypical apolipoprotein and, based on its primary structure, Apolipoprotein-D is a member of the lipocalin family. Lipocalins adopt a beta-barrel tertiary structure and transport small hydrophobic ligands. Apolipoprotein-D binds cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid. Apolipoprotein-D is expressed in numerous tissues having high levels of expression in spleen, testes and brain. Apolipoprotein-D is present at high concentrations in the cyst fluid of women with gross cystic disease of the breast, a condition associated with increased risk of breast cancer. Apolipoprotein-D accumulates in regenerating peripheral nerves and in the cerebrospinal fluid of patients with neurodegenerative conditions, such as Alzheimer's disease. Apolipoprotein-D participates in maintenance and repair within the central and peripheral nervous systems. Apolipoprotein-D is a multi-ligand, multi-functional transporter and transports a ligand from 1 cell to another within an organ, scavenge a ligand within an organ for transport to the blood or could transport a ligand from the circulation to specific cells within a tissue.

Product Categories/Family for APOD recombinant protein

Cytokines and Growth Factors; Cytokines; Apolipoprotein

NCBI and Uniprot Product Information

• NCBI GI #: 4502163
• NCBI GeneID: 347
• NCBI Accession #: NP_001638.1
• NCBI GenBank Nucleotide #: NM_001647.3
• UniProt Accession #: P05090; Q6IBG6; B2R579; D3DNW6
• Molecular Weight: 21,276 Da
• NCBI Official Full Name: apolipoprotein D
• NCBI Official Synonym Full Names: apolipoprotein D
• NCBI Official Symbol: APOD
• NCBI Protein Information: apolipoprotein D; apo-D
• UniProt Protein Name: Apolipoprotein D
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOD
• UniProt Synonym Gene Names: Apo-D; ApoD
• UniProt Entry Name: APOD_HUMAN

NCBI Description

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

Uniprot Description

APOD: APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Lipid-binding; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell soma; perinuclear region of cytoplasm; endoplasmic reticulum; dendrite; extracellular region

Molecular Function: lipid transporter activity; protein binding; cholesterol binding

Biological Process: response to drug; negative regulation of smooth muscle cell proliferation; negative regulation of focal adhesion formation; glucose metabolic process; negative regulation of protein import into nucleus; lipid transport; axon regeneration in the peripheral nervous system; response to reactive oxygen species; tissue regeneration; lipid metabolic process; response to axon injury; brain development; angiogenesis; aging