Apolipoprotein CIII Protein | ApoCIII protein
Apolipoprotein CIII (ApoCIII), Human - Ultra Pure
Shipping: Dry Ice.
Technical support, bulk quantities and aliquoting available.
This product is purified from delipidated VLDL (very low density lipoprotein) and is purified through affinity chromotography.
Normal plasma concentration of Human Apolipoprotein CIII (Apo-CIII)is 8-15 mg/dL. The physiological role of human Apo-CIII is unclear, although it may inhibit the activation of lipoprotein lipase by Apo-CII.
NCBI and Uniprot Product Information
NCBI Description
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
Uniprot Description
APOC3: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles. Defects in APOC3 are the cause of hyperalphalipoproteinemia type 2 (HALP2). HALP2 is a condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Belongs to the apolipoprotein C3 family.
Protein type: Secreted; Lipid-binding; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: extracellular space; chylomicron; early endosome; extracellular region
Molecular Function: lipase inhibitor activity; cholesterol binding; phospholipid binding; enzyme regulator activity
Biological Process: response to drug; cholesterol metabolic process; response to peptide hormone stimulus; phototransduction, visible light; regulation of Cdc42 protein signal transduction; lipoprotein metabolic process; cholesterol efflux; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; negative regulation of lipid catabolic process; phospholipid efflux; lipoprotein transport; triacylglycerol catabolic process; negative regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; triacylglycerol mobilization; negative regulation of lipid metabolic process; retinoid metabolic process; inflammatory response; response to nutrient; negative regulation of fatty acid biosynthetic process
Disease: Apolipoprotein C-iii Deficiency
Research Articles on ApoCIII
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Product Notes
The ApoCIII apoc3 (Catalog #AAA173231) is a Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Apolipoprotein CIII, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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