Monkey apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H ELISA Kit | APOBEC3H elisa kit
Monkey DNA dC->dU-editing enzyme APOBEC-3H, APOBEC3H ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.3 PublicationsManual assertion based on experiment in:Ref.1
Catalytic activity: Cytidine + H2O = uridine + NH3.
Cofactor: Zinc
Enzyme regulation: Antiviral activity is neutralized by the simian immunodeficiency virus rhesus (SIV-mac) virion infectivity factor (VIF).1 PublicationManual assertion based on experiment in:Ref.4
Research Articles on APOBEC3H
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Product Notes
The Monkey APOBEC3H apobec3h (Catalog #AAA9319247) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319247 ELISA Kit recognizes Monkey APOBEC3H. It is sometimes possible for the material contained within the vial of "apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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