Apolipoprotein-B Recombinant Protein | APOB recombinant protein

Human Apolipoprotein-B

Cat. Num. AAA147069

• Gene Names: APOB; FLDB; LDLCQ4; apoB-48; apoB-100
• Purity: Greater than 95.0%
• Synonyms: Apolipoprotein-B; Human Apolipoprotein-B; APOB; APO-B; Apolipoprotein B; APOB Human; Apolipoprotein-B Human; APOB recombinant protein

• Host: Human Plasma
• Purity/Purification: Greater than 95.0%
• Form/Format: Sterile filtered lyophilized (freeze-dried) powder; Protein was lyophilized from a 0.5mg/ml solution of 50mM Na2CO3 pH-10 containing 50mM NaCl and 10mM sodium deoxycholate
• Sequence Length: 1670

• Human Virus Test: Starting material donor has been tested and certified negative for antibodies to HIV-1, HIV-2, HCV, HBSAG
• Solubility: It is recommended to reconstitute the lyophilized APOB in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions
• Preparation and Storage: Although stable at room temperature for 3 weeks, should be stored desiccated below-18 degree C.; Upon reconstitution, APOB should be stored at 4 degree C between 2-7 days and for future use below-18 degree C. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles

Related Product Information for APOB recombinant protein

Description: Human APOB produced from Human plasma having a molecular mass of 550 kDa.
Introduction: ApoB is the main apolipoprotein of LDL, IDL, VLDL and chylomicrons particles that serves as the carrier of lipids (fat molecules), as well as cholesterol, in the water surrounding the cells within every tissue across the body. Though all the functional aspects of Apolipoprotein B within the LDL and other elements are considered to be rather uncertain, it serves as the key organizing protein of all other carriers of lipids. across LDL membranes, apolipoprotein B also serves as a ligand for LDL receptors in many cells across the body, meaning, it shows that lipid carriers that are set to cross into cells with Apolipoprotein B receptors, this is the way that lipids are transported within and into cells.

Product Categories/Family for APOB recombinant protein

Cytokines and Growth Factors; Cytokines; Apolipoprotein; APOB Human

NCBI and Uniprot Product Information

• NCBI GI #: 553189
• NCBI GeneID: 338
• Molecular Weight: 515,605 Da
• NCBI Official Full Name: apolipoprotein B, partial
• NCBI Official Synonym Full Names: apolipoprotein B
• NCBI Official Symbol: APOB
• NCBI Official Synonym Symbols: FLDB; LDLCQ4; apoB-48; apoB-100
• NCBI Protein Information: apolipoprotein B-100
• UniProt Protein Name: Apolipoprotein B-100
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOB
• UniProt Synonym Gene Names: Apo B-100; Apo B-48

NCBI Description

This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]

Uniprot Description

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.