Apolipoprotein AII Protein | ApoA2 protein

Apolipoprotein AII (ApoAII, ApoA2), Human Serum - Ultra Pure

Cat. Num. AAA173021

• Gene Names: APOA2; apoAII; Apo-AII; ApoA-II
• Purity: >= 98% (SDS-PAGE)
• Synonyms: Apolipoprotein AII; Apolipoprotein AII (ApoAII; ApoA2); Human Serum - Ultra Pure; Apolipoprotein AII (APO AII); Human Serum - >=99% (SDS-PAGE); ApoA2 protein

• Purity/Purification: >= 98% (SDS-PAGE)
• Form/Format: 20mM Tris-HCl, 140mM sodium chloride, 0.5mM EDTA pH 8.0 with 0.02% sodium azide.; ; Appearance: Frozen Liquid
• Concentration: Protein Concentration: 1.0 - 5.0 mg/mL (Lowry) (varies by lot)
• Sequence Length: 100

• Source: Human Plasma
• UNSPSC Code: 51131909
• Protein: 1.0mg/ml (Lowry)
• Recertification: 2 years
• Preparation and Storage: At -20 degree C

Related Product Information for ApoA2 protein

MyBioSource sells human serum Apolipoprotein AII (ApoAII) for research, life science, and manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available.

Ultra pure human Apolipoprotein AII is purified from delipidated HDL and is one of a family of evolutionarily related proteins which play a crucial role in lipid transport and metabolism. Serum levels of human ApoAII have been shown to be inversely correlated to the incidence of coronary heart disease and its expression to be limited to the liver and intestine.

Product Categories/Family for ApoA2 protein

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Apolipoprotein Aii (apo Aii)

NCBI and Uniprot Product Information

• NCBI GI #: 4502149
• NCBI GeneID: 336
• NCBI Accession #: NP_001634.1
• NCBI GenBank Nucleotide #: NM_001643.1
• Molecular Weight: ~17kDa
• NCBI Official Full Name: apolipoprotein A-II preproprotein
• NCBI Official Synonym Full Names: apolipoprotein A-II
• NCBI Official Symbol: APOA2
• NCBI Official Synonym Symbols: apoAII; Apo-AII; ApoA-II
• NCBI Protein Information: apolipoprotein A-II; apolipoprotein A2
• UniProt Protein Name: Apolipoprotein A-II
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOA2
• UniProt Synonym Gene Names: Apo-AII; ApoA-II; ProapoA-II
• UniProt Entry Name: APOA2_HUMAN

NCBI Description

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Uniprot Description

APOA2: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Belongs to the apolipoprotein A2 family.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: chylomicron; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol

Molecular Function: lipid transporter activity; protein binding; protein homodimerization activity; lipase inhibitor activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; high-density lipoprotein binding; lipid binding; apolipoprotein receptor binding

Biological Process: positive regulation of catalytic activity; phototransduction, visible light; viral reproduction; protein folding; negative regulation of cholesterol transport; response to glucocorticoid stimulus; regulation of protein stability; diacylglycerol catabolic process; positive regulation of lipid catabolic process; cellular lipid metabolic process; negative regulation of lipase activity; negative regulation of lipid catabolic process; phospholipid efflux; regulation of cholesterol absorption; response to glucose stimulus; retinoid metabolic process; response to drug; cholesterol metabolic process; organ regeneration; protein amino acid oxidation; phospholipid catabolic process; positive regulation of interleukin-8 biosynthetic process; cholesterol efflux; lipoprotein metabolic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; triacylglycerol metabolic process; reverse cholesterol transport; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; acute inflammatory response

Disease: Hypercholesterolemia, Familial