Adenomatous polyposis coli protein 2 (APC2) Recombinant Protein | APC2 recombinant protein

Recombinant Human Adenomatous polyposis coli protein 2 (APC2) , partial

• Gene Names: APC2; APCL
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Adenomatous polyposis coli protein 2 (APC2); Recombinant Human Adenomatous polyposis coli protein 2 (APC2); partial; APC2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2,302

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 5031587
• NCBI GeneID: 10297
• NCBI Accession #: NP_005874.1
• NCBI GenBank Nucleotide #: NM_005883.2
• UniProt Accession #: O95996; Q05BW4; Q9UBZ1; Q9UEM8; Q9UQJ8; Q9UQJ9; Q9Y632
• Molecular Weight: 243,821 Da
• NCBI Official Full Name: adenomatous polyposis coli protein 2 isoform 1
• NCBI Official Synonym Full Names: APC2, WNT signaling pathway regulator
• NCBI Official Symbol: APC2
• NCBI Official Synonym Symbols: APCL
• NCBI Protein Information: adenomatous polyposis coli protein 2
• UniProt Protein Name: Adenomatous polyposis coli protein 2
• Protein Family: Acetophenone carboxylase
• UniProt Gene Name: APC2
• UniProt Synonym Gene Names: APCL; APC-like

NCBI Description

This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

Uniprot Description

Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).