Rat Adenomatous polyposis coli ELISA Kit | APC elisa kit
Rat Adenomatous polyposis coli (APC) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
NCBI Description
binds microtubules; may play a role in the regulation of cell polarity [RGD, Feb 2006]
Uniprot Description
APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 18p12
Cellular Component: axon; axonal growth cone; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell cortex; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; microtubule; neuron projection; neuron projection terminus; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; Scrib-APC-beta-catenin complex; synapse
Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein complex binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process: anterior/posterior pattern specification; axis specification; axonogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell cycle arrest; cell migration; cellular response to DNA damage stimulus; chromosome organization and biogenesis; cytoplasmic microtubule organization; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; insulin receptor signaling pathway; kidney development; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; muscle maintenance; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt signaling pathway; neuron projection development; pancreas development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; protein complex assembly; protein homooligomerization; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of glutamate metabolic process; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; response to alcohol; response to drug; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in thymus; thymus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Research Articles on APC
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Product Notes
The Rat APC apc (Catalog #AAA284232) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA284232 ELISA Kit recognizes Rat APC. It is sometimes possible for the material contained within the vial of "Adenomatous polyposis coli, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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