AP-1 complex subunit sigma-3 Recombinant Protein | AP1S3 recombinant protein

Recombinant Human AP-1 complex subunit sigma-3

Cat. Num. AAA9419996

• Gene Names: AP1S3; PSORS15
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: AP-1 complex subunit sigma-3; Recombinant Human AP-1 complex subunit sigma-3; Adaptor protein complex AP-1 subunit sigma-1C; Adaptor-related protein complex 1 subunit sigma-1C; Clathrin assembly protein complex 1 sigma-1C small chain; Golgi adaptor HA1/AP1 adaptin sigma-1C subunit; Sigma 1C subunit of AP-1 clathrin; Sigma-adaptin 1C; Sigma1C-adaptin; AP1S3 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: 1-104aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for AP1S3 recombinant protein

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to mbranes and the recognition of sorting signals within the cytosolic tails of transmbrane cargo molecules. Involved in TLR3 trafficking.

NCBI and Uniprot Product Information

• NCBI GI #: 88703051
• NCBI GeneID: 130340
• NCBI Accession #: NP_001034658.1
• NCBI GenBank Nucleotide #: NM_001039569.1
• UniProt Accession #: Q96PC3; Q8WTY1; Q96DD1; B4DQZ1
• Molecular Weight: 40kD
• NCBI Official Full Name: AP-1 complex subunit sigma-3
• NCBI Official Synonym Full Names: adaptor related protein complex 1 sigma 3 subunit
• NCBI Official Symbol: AP1S3
• NCBI Official Synonym Symbols: PSORS15
• NCBI Protein Information: AP-1 complex subunit sigma-3
• UniProt Protein Name: AP-1 complex subunit sigma-3
• Protein Family: AP-1 complex
• UniProt Gene Name: AP1S3

NCBI Description

This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

AP1S3: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Belongs to the adaptor complexes small subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: cytoplasmic vesicle membrane; cytosol; Golgi membrane; intracellular membrane-bound organelle; lysosomal membrane; trans-Golgi network membrane

Molecular Function: protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; protein targeting; regulation of defense response to virus by virus

Disease: Psoriasis 15, Pustular, Susceptibility To