ANTXR2 recombinant protein

ANTXR2 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8123158

• Gene Names: Antxr2; CMG2; CMG-2; cI-35; AW561899; 2310046B19Rik
• Purity: >95% as determined by SDS-PAGE
• Synonyms: ANTXR2; ANTXR2 Protein; Mouse; Recombinant (His Tag); Mouse ANTXR2/CMG2 Protein (His Tag); 2310046B19Rik Protein; AW561899 Protein; cI-35 Protein; CMG-2 Protein; CMG2 Protein; anthrax toxin receptor 2; ANTXR2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Gly318

• Species: Mouse
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Gln 32
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain of mouse ANTXR2 (NP_598499.1)(Met1-Gly318) was expressed with a C-terminal polyhistidine tag.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for ANTXR2 recombinant protein

Background: Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 50355939
• NCBI GeneID: 71914
• NCBI Accession #: NP_598499.1
• NCBI GenBank Nucleotide #: NM_133738.1
• UniProt Accession #: Q6DFX2; Q99L17
• Molecular Weight: 53,184 Da
• NCBI Official Full Name: anthrax toxin receptor 2
• NCBI Official Synonym Full Names: anthrax toxin receptor 2
• NCBI Official Symbol: Antxr2
• NCBI Official Synonym Symbols: CMG2; CMG-2; cI-35; AW561899; 2310046B19Rik
• NCBI Protein Information: anthrax toxin receptor 2
• UniProt Protein Name: Anthrax toxin receptor 2
• Protein Family: Anthrax toxin receptor
• UniProt Gene Name: Antxr2

Uniprot Description

ANTXR2: Necessary for cellular interactions with laminin and the extracellular matrix. Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH). This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures. Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF). JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 5|5 E3

Cellular Component: cell surface; external side of plasma membrane; integral to membrane

Biological Process: reproductive process