ANTXR2 recombinant protein

ANTXR2 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121958

• Gene Names: ANTXR2; HFS; ISH; JHF; CMG2; CMG-2
• Purity: >85% as determined by SDS-PAGE
• Synonyms: ANTXR2; ANTXR2 Protein; Human; Recombinant (hFc Tag); Human ANTXR2/CMG2 Protein (Fc Tag); CMG-2 Protein; CMG2 Protein; HFS Protein; ISH Protein; JHF Protein; anthrax toxin receptor 2; ANTXR2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Asn317

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Gln 34
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human ANTXR2 (NP_477520.2)(Met1-Asn317) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for ANTXR2 recombinant protein

Background: Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS identified that anthrax roxin receptor 2 (ANTXR2) was one of the risk loci for ankylosing spondylitis (AS). Previous study also showed that ANTXR2 could potentially affect new bone formation. This study aimed to investigate the possible mechanisms of ANTXR2 involved in AS pathogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 50513243
• NCBI GeneID: 118429
• NCBI Accession #: NP_477520.2
• NCBI GenBank Nucleotide #: NM_058172.5
• UniProt Accession #: P58335; Q4W5H6; Q59E98; Q5JPE9; Q86UI1; Q8N4J8; Q8NB13; Q96NC7
• Molecular Weight: 53,493 Da
• NCBI Official Full Name: anthrax toxin receptor 2 isoform 1
• NCBI Official Synonym Full Names: anthrax toxin receptor 2
• NCBI Official Symbol: ANTXR2
• NCBI Official Synonym Symbols: HFS; ISH; JHF; CMG2; CMG-2
• NCBI Protein Information: anthrax toxin receptor 2; capillary morphogenesis protein 2; capillary morphogenesis gene 2 protein
• UniProt Protein Name: Anthrax toxin receptor 2
• Protein Family: Anthrax toxin receptor
• UniProt Gene Name: ANTXR2
• UniProt Synonym Gene Names: CMG2; CMG-2

NCBI Description

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

Necessary for cellular interactions with laminin and the extracellular matrix.