Galectin-3 Antigen | LGALS3 antigen
Human Galectin-3 protein
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]
Uniprot Description
galectin-3: galactose-specific lectin which binds IgE. Expressed at a high level in the colonic epithelium. Also abundant in activated macrophages.
Protein type: Cell surface; Extracellular matrix; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q22.3
Cellular Component: cytoplasm; extracellular matrix; extracellular space; immunological synapse; membrane; mitochondrial inner membrane; nucleus; plasma membrane
Molecular Function: chemoattractant activity; IgE binding; laminin binding; protein binding
Biological Process: eosinophil chemotaxis; epithelial cell differentiation; macrophage chemotaxis; monocyte chemotaxis; negative regulation of endocytosis; negative regulation of T cell receptor signaling pathway; neutrophil chemotaxis; positive chemotaxis; regulation of T cell proliferation
Research Articles on LGALS3
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Product Notes
The LGALS3 lgals3 (Catalog #AAA7041638) is an Antigen and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Galectin-3 can be used in a range of immunoassay formats including, but not limited to, Calibrator, Western Blot (WB). Researchers should empirically determine the suitability of the LGALS3 lgals3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Galectin-3, Antigen" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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