CHLAMYDIA TRACHOMATIS Antigen

NATIVE CHLAMYDIA TRACHOMATIS

Cat. Num. AAA239123

• Applications: ELISA
• Synonyms: CHLAMYDIA TRACHOMATIS; NATIVE CHLAMYDIA TRACHOMATIS; CHLAMYDIA TRACHOMATIS antigen

• Form/Format: Inactivated Pathogen; Inactivated Chlamydia trachomatis - liquid.; Phosphate buffered saline

• Applicable Applications for CHLAMYDIA TRACHOMATIS antigen: Immunoassay (IY), ELISA (EIA)
• Source: Chlamydia trachomatis LGV type II strain 434 cultured in mouse L cells.
• Preparation: Mouse L cells are infected with Chlamydia trachomatis LGV type II strain 434 elementary bodies. Optimally infected cells are harvested and disrupted by sonication in phosphate bufffered saline. Cellular debris is removed by centrifugation. The antigen preparation is inactivated using gamma radiation, which primarily damages chlamydial genetic material.
• Instructions For Use: This item should be sonicated immediately before use to ensure the preparation is uniform. The product may be used in a variety of immunoassay formats or may be further purified to meet the requirements of a particular assay format.
• Activity: This product has been rendered inactive by standard procedures. However this material should still be handled as infectious and should be disposed of appropriately.
• Target Species: Bacterial
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Ships on dry ice. Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.

Related Product Information for CHLAMYDIA TRACHOMATIS antigen

Chlamydia trachomatis is a nonmotile, Gram-negative human pathogen. It undergoes a unique biphasic developmental cycle, forming elementary bodies extracellularly and distinctive intracellular inclusions. The elementary body is infectious but metabolically inactive, cannot replicate and lacks detectable peptidoglycan. The major outer membrane protein (MOMP) comprises a large percentage of the outer membrane and is a transmembrane protein with type, species and genus reactive epitopes. The outer membrane also carries a heat stable lipopolysaccharide containing the reactive epitopes used for genus specific serological tests. There is structural similarity and antigenic cross-reactivity between chlamydial and other Gram-negative LPS moieties. Chlamydia trachomatis is a common sexually transmitted bacterium. Chlamydia infection may cause proctitis, urethritis, trachoma (an eye infection and the leading cause of blindness worldwide) and infertility in both sexes. Prostatitis and epididymitis may occur in men and in women infection might lead to acute or chronic pelvic pain, pelvic inflammatory disease, cervicitis and ectopic pregnancy. In neonates the pathogen may cause trachoma and pulmonary complications. MBS239123 contains a high concentration of elementary bodies and chlamydial components in phosphate buffered saline. Residual host cellular material is present.