SH3GLB1 Antibody | anti-SH3GLB1 antibody

SH3GLB1 Antibody

Gene Names

SH3GLB1; Bif-1; CGI-61; PPP1R70; dJ612B15.2

Synonyms

SH3GLB1; SH3GLB1 Antibody; anti-SH3GLB1 antibody

Ordering
Cat. Num. AAA8505327 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Sequence Length

394

NCBI and Uniprot Product Information

NCBI GI #

331284170

NCBI GeneID

51100

NCBI Accession #

NP_001193580.1

NCBI GenBank Nucleotide #

NM_001206651.1

UniProt Accession #

Q9Y371; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; B4E182

Molecular Weight

29,318 Da

NCBI Official Full Name

endophilin-B1 isoform 2

NCBI Official Synonym Full Names

SH3 domain containing GRB2 like, endophilin B1

NCBI Official Symbol

SH3GLB1

NCBI Official Synonym Symbols

Bif-1; CGI-61; PPP1R70; dJ612B15.2

NCBI Protein Information

endophilin-B1

UniProt Protein Name

Endophilin-B1

Protein Family

Endophilin

UniProt Gene Name

SH3GLB1

UniProt Synonym Gene Names

KIAA0491; Bif-1

NCBI Description

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Description

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability ().

Research Articles on SH3GLB1

1. Here the authors report that Endophilin B2, similarly to Endophilin B1, plays an indispensable role in mitochondria sequestration and inner mitochondrial membrane (IMM) protein degradation during mitophagy.

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Product Notes

The SH3GLB1 sh3glb1 (Catalog #AAA8505327) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SH3GLB1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SH3GLB1 Antibody | anti-SH3GLB1 antibody