NKRF Antibody | anti-NKRF antibody

NKRF Antibody

Cat. Num. AAA8502825

• Gene Names: NKRF; NRF; ITBA4
• Synonyms: NKRF; NKRF Antibody; anti-NKRF antibody

• Sequence Length: 705

NCBI and Uniprot Product Information

• NCBI GI #: 291084505
• NCBI GeneID: 55922
• NCBI Accession #: NP_001166958.1
• NCBI GenBank Nucleotide #: NM_001173487.1
• UniProt Accession #: O15226; Q4VC41; Q9UJ91; G3V1N1
• Molecular Weight: 79,496 Da
• NCBI Official Full Name: NF-kappa-B-repressing factor isoform 1
• NCBI Official Synonym Full Names: NFKB repressing factor
• NCBI Official Symbol: NKRF
• NCBI Official Synonym Symbols: NRF; ITBA4
• NCBI Protein Information: NF-kappa-B-repressing factor
• UniProt Protein Name: NF-kappa-B-repressing factor
• Protein Family: NF-kappa-B-repressing factor
• UniProt Gene Name: NKRF
• UniProt Synonym Gene Names: ITBA4; NRF; NFkB-repressing factor

NCBI Description

This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Uniprot Description

Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.