<
Western Blot (WB)
(Western Blot analysis of K562 cells with JAB1 Polyclonal Antibody.)
Tumor Suppressor Inactivation Antibody Kit
Tumor Suppressor Inactivation Antibody Sampler Kit
Applications
Western Blot
Synonyms
Tumor Suppressor Inactivation; Tumor Suppressor Inactivation Antibody Sampler Kit; Tumor Suppressor Inactivation antibody kit
Applicable Applications for Tumor Suppressor Inactivation antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of K562 cells with JAB1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of K562 cells with JAB1 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of COLO205 cells using p27 Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of COLO205 cells using p27 Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of A549 cells with p53 Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of A549 cells with p53 Polyclonal Antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse testis tissue using Smad4 Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Mouse testis tissue using Smad4 Polyclonal Antibody at dilution of 1:200.)
Related Product Information for Tumor Suppressor Inactivation antibody kit
Background: COPS5/CSN5/Jab1 (c-Jun activation domain-binding protein-1) was originally identified as a transcriptional coactivator of c-Jun and subsequently discovered to be a fifth component and integral part of the CSN. As the catalytic center of the CSN, COPS5 is able to integrate multiple functions of the CSN complex such as cell cycle control, transcription, and DNA damage response by regulating the activity of CRLs through deneddylation of cullins. Indeed, COPS5 harbors an Mpr1-Pad1-N-terminal (MPN) domain with an embedded Jab1/CSN5 MPN domain metalloenzyme (JAMM) motif that is essential for the CSN isopeptidase activity responsible for deneddylation of CRLs. COPS5 is an evolutionarily conserved 38 kDa protein in humans, mice, fission yeast, and plants, which suggests that it is critical to cell survival and proliferation. A role for COPS5 as a positive regulator of cellular proliferation is supported by evidence that it functionally inactivates several key tumor suppressors such as p53, RUNX3, Smad4, and p27 Kip1 through altered subcellular localization, degradation, and deneddylation. These findings are underscored by the observation that COPS5 overexpression has been identified in a number of different tumor types and has been implicated in the initiation and progression of several types of cancer. Moreover, COPS5 deficient mice display an embryonically lethal phenotype highlighted by elevated expression of COPS5 targets such as p53 and p27.
Similar Products
Product Notes
The Tumor Suppressor Inactivation (Catalog #AAA2550143) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Tumor Suppressor Inactivation can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Tumor Suppressor Inactivation for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tumor Suppressor Inactivation, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
