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Western Blot (WB)
(Western Blot analysis of 293 cells using PAKalpha Polyclonal Antibody at dilution of 1:500.)
PAK 1/2/3 antibody kit
PAK 1/2/3 Antibody Sampler Kit
Applications
Western Blot
Synonyms
PAK 1/2/3; PAK 1/2/3 Antibody Sampler Kit; PAK 1/2/3 antibody kit
Applicable Applications for PAK 1/2/3 antibody kit
Western Blot (WB)
Western Blot (WB)
(Western Blot analysis of 293 cells using PAKalpha Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of 293 cells using PAKalpha Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-PAKalpha (Thr212) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 293T cells with Phospho-PAKalpha (Thr212) Polyclonal Antibody)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-PAKalpha (Ser204) Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with Phospho-PAKalpha (Ser204) Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with PAKalpha/beta/gamma Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with PAKalpha/beta/gamma Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with PAKgamma Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 3T3 cells with PAKgamma Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-PAKgamma (Ser20) Polyclonal Antibody.)
Western Blot (WB)
(Western Blot analysis of 293 cells with Phospho-PAKgamma (Ser20) Polyclonal Antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human esophagus cancer using PAK3 Polyclonal Antibody at dilution of 1/25)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human esophagus cancer using PAK3 Polyclonal Antibody at dilution of 1/25)
Related Product Information for PAK 1/2/3 antibody kit
Background: The p21-activated kinase (PAK) family of serine/threonine kinases is engaged in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, control of phagocyte NADPH oxidase and growth factor-induced neurite outgrowth. Several mechanisms that induce PAK activity have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain near the amino terminus of PAK causes autophosphorylation and conformational changes in PAK. Phosphorylation of PAK1 at Thr423 by PDK induces activation of PAK1. Several autophosphorylation sites have been identified, including serines 199 and 204 of PAK1 and serines 192 and 197 of PAK2. Because the autophosphorylation sites are located in the amino- terminal inhibitory domain, it has been hypothesized that modification in this region prevents the kinase from reverting to an inactive conformation. Research indicates that phosphorylation of Ser144 of PAK1 or Ser139 of PAK3 (located in the kinase inhibitory domain) affects kinase activity. Phosphorylation of Ser21 of PAK1 or Ser20 of PAK2 regulates binding with the adaptor protein Nck.
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Product Notes
The PAK 1/2/3 (Catalog #AAA2550067) is an Antibody Kit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PAK 1/2/3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the PAK 1/2/3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PAK 1/2/3, Antibody Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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