Typical Testing Data/Standard Curve (for reference only)
Rat Anti-Neuronal Nuclear AutoAntibody 1 ELISA Kit | ANNA1 elisa kit
Rat Anti-Neuronal Nuclear AutoAntibody 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
plays a role in regulation of insulin secretion; may inhibit phopsholipase A2 [RGD, Feb 2006]
Uniprot Description
ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Lipid-binding; Calcium-binding
Cellular Component: extracellular space; focal adhesion; protein complex; cell surface; mast cell granule; basolateral plasma membrane; cornified envelope; cilium; mitochondrial membrane; cytoplasm; plasma membrane; nucleus; sarcolemma; vesicle; endosome
Molecular Function: protein binding, bridging; single-stranded RNA binding; protein homodimerization activity; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; helicase activity; calcium-dependent protein binding; single-stranded DNA binding
Biological Process: prostate gland development; response to peptide hormone stimulus; positive regulation of apoptosis; response to glucocorticoid stimulus; response to hormone stimulus; alpha-beta T cell differentiation; positive regulation of vesicle fusion; signal transduction; response to organic cyclic substance; response to estradiol stimulus; response to corticosteroid stimulus; cell surface receptor linked signal transduction; positive regulation of prostaglandin biosynthetic process; response to X-ray; response to drug; negative regulation of protein secretion; positive regulation of neutrophil apoptosis; gliogenesis; arachidonic acid secretion; neutrophil homeostasis; endocrine pancreas development; DNA duplex unwinding; regulation of cell proliferation; keratinocyte differentiation; insulin secretion; DNA strand renaturation; peptide cross-linking
Research Articles on ANNA1
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Product Notes
The Rat ANNA1 anxa1 (Catalog #AAA724922) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA724922 ELISA Kit recognizes Rat ANNA1. It is sometimes possible for the material contained within the vial of "Anti-Neuronal Nuclear AutoAntibody 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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