Ankyrin repeat domain-containing protein 17 (ANKRD17) Recombinant Protein | ANKRD17 recombinant protein

Recombinant Human Ankyrin repeat domain-containing protein 17 (ANKRD17) , partial

• Gene Names: ANKRD17; GTAR; MASK2; NY-BR-16
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ankyrin repeat domain-containing protein 17 (ANKRD17); Recombinant Human Ankyrin repeat domain-containing protein 17 (ANKRD17); partial; ANKRD17 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 2490

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for ANKRD17 recombinant protein

This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 557948112
• NCBI GeneID: 26057
• NCBI Accession #: NP_001273700.1
• NCBI GenBank Nucleotide #: NM_001286771.2
• UniProt Accession #: O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9; E7EUV3; G5E964
• Molecular Weight: 263,556 Da
• NCBI Official Full Name: ankyrin repeat domain-containing protein 17 isoform c
• NCBI Official Synonym Full Names: ankyrin repeat domain 17
• NCBI Official Symbol: ANKRD17
• NCBI Official Synonym Symbols: GTAR; MASK2; NY-BR-16
• NCBI Protein Information: ankyrin repeat domain-containing protein 17
• UniProt Protein Name: Ankyrin repeat domain-containing protein 17
• Protein Family: Ankyrin repeat domain-containing protein
• UniProt Gene Name: ANKRD17
• UniProt Synonym Gene Names: GTAR; KIAA0697

NCBI Description

The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system ().