Human alkB, alkylation repair homolog 2 (E. coli) ELISA Kit | ALKBH2 elisa kit
Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, ALKBH2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Uniprot Description
ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Demethylase; Hydrolase; DNA repair, damage; Oxidoreductase; EC 1.14.11.33
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: nucleoplasm; microtubule cytoskeleton; nucleus
Molecular Function: ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity
Biological Process: DNA dealkylation; DNA repair
Research Articles on ALKBH2
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Product Notes
The Human ALKBH2 alkbh2 (Catalog #AAA9332014) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332014 ELISA Kit recognizes Human ALKBH2. It is sometimes possible for the material contained within the vial of "alkB, alkylation repair homolog 2 (E. coli), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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