Mouse asparagine-linked glycosylation 8, alpha-1, 3-glucosyltransferase homolog (S. cerevisiae) ELISA Kit | ALG8 elisa kit
Mouse Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1, 3-glucosyltransferase, ALG8 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ALG8: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the ALG6/ALG8 glucosyltransferase family.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Transferase; Membrane protein, integral; Membrane protein, multi-pass; EC 2.4.1.265
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; transferase activity; transferase activity, transferring glycosyl groups; transferase activity, transferring hexosyl groups; alpha-1,3-mannosyltransferase activity
Biological Process: oligosaccharide-lipid intermediate assembly; protein amino acid N-linked glycosylation
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Product Notes
The Mouse ALG8 alg8 (Catalog #AAA9327812) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327812 ELISA Kit recognizes Mouse ALG8. It is sometimes possible for the material contained within the vial of "asparagine-linked glycosylation 8, alpha-1, 3-glucosyltransferase homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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