Human asparagine-linked glycosylation 3, alpha-1, 3- mannosyltransferase homolog (S. cerevisiae) ELISA Kit | ALG3 elisa kit
Human Dol-P-Man:Man, ALG3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Description
ALG3: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D); also known as carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. Belongs to the glycosyltransferase 58 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; Transferase; Endoplasmic reticulum; EC 2.4.1.258
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: alpha-1,3-mannosyltransferase activity
Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification
Disease: Congenital Disorder Of Glycosylation, Type Id
Research Articles on ALG3
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Product Notes
The Human ALG3 alg3 (Catalog #AAA9322841) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322841 ELISA Kit recognizes Human ALG3. It is sometimes possible for the material contained within the vial of "asparagine-linked glycosylation 3, alpha-1, 3- mannosyltransferase homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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