A-kinase anchor protein 8-like (AKAP8L) Recombinant Protein | AKAP8L recombinant protein

Recombinant Human A-kinase anchor protein 8-like (AKAP8L)

Cat. Num. AAA1309456

• Gene Names: AKAP8L; HA95; HAP95; NAKAP; NAKAP95
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: A-kinase anchor protein 8-like (AKAP8L); Recombinant Human A-kinase anchor protein 8-like (AKAP8L); AKAP8L recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-646, Full length protein
• Sequence: MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIHQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP
• Sequence Length: 646

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 612407792
• NCBI GeneID: 26993
• NCBI Accession #: NP_001278407.1
• NCBI GenBank Nucleotide #: NM_001291478.1
• UniProt Accession #: Q9ULX6; O94792; Q96J58; Q9NRQ0; Q9UGM0; B4DJ74; B5BU90
• Molecular Weight: 65,230 Da
• NCBI Official Full Name: A-kinase anchor protein 8-like isoform 2
• NCBI Official Synonym Full Names: A-kinase anchoring protein 8 like
• NCBI Official Symbol: AKAP8L
• NCBI Official Synonym Symbols: HA95; HAP95; NAKAP; NAKAP95
• NCBI Protein Information: A-kinase anchor protein 8-like
• UniProt Protein Name: A-kinase anchor protein 8-like
• Protein Family: A-kinase anchor protein
• UniProt Gene Name: AKAP8L
• UniProt Synonym Gene Names: NAKAP; NAKAP95; AKAP8-like protein; HAP95; HA95; Neighbor of AKAP95

Uniprot Description

Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).