Guinea Pig A-kinase anchor protein 13 ELISA Kit | AKAP13 elisa kit

Guinea pig A-kinase anchor protein 13 (AKAP13) ELISA Kit

Gene Names

AKAP13; BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC

Reactivity

Guinea Pig

Synonyms

A-kinase anchor protein 13; Guinea pig A-kinase anchor protein 13 (AKAP13) ELISA Kit; AKAP13 elisa kit

Ordering
Cat. Num. AAA2607591 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Guinea Pig

Sequence Length

1434

Preparation and Storage

Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

NCBI GI #

395627649

NCBI GeneID

11214

NCBI Accession #

NP_001257475.1

NCBI GenBank Nucleotide #

NM_001270546.1

Molecular Weight

19,992 Da

NCBI Official Full Name

A-kinase anchor protein 13 isoform 4

NCBI Official Synonym Full Names

A-kinase anchoring protein 13

NCBI Official Symbol

AKAP13

NCBI Official Synonym Symbols

BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC

NCBI Protein Information

A-kinase anchor protein 13

UniProt Protein Name

A-kinase anchor protein 13

Protein Family

A-kinase anchor protein

UniProt Gene Name

AKAP13

UniProt Synonym Gene Names

BRX; HT31; LBC; AKAP-13; LBC oncogene; PRKA13

UniProt Entry Name

AKP13_HUMAN

NCBI Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

Uniprot Description

AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho; Oncoprotein; Adaptor/scaffold; Nuclear receptor co-regulator; Nuclear export

Chromosomal Location of Human Ortholog: 15q24-q25

Cellular Component: cytoplasm; cytosol; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: cAMP-dependent protein kinase activity; metal ion binding; protein binding; protein complex scaffold; protein kinase A binding; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity

Biological Process: nerve growth factor receptor signaling pathway; nuclear export; positive regulation of apoptosis; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of protein kinase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction

Research Articles on AKAP13

1. Isothermal titration calorimetry showed that AKAP-Lbc has only micromolar affinity for RhoA, which combined with the presence of potential binding pockets for small molecules on AKAP-Lbc, raises the possibility of targeting AKAP-Lbc with GEF inhibitors.

Similar Products

Product Notes

The Guinea Pig AKAP13 akap13 (Catalog #AAA2607591) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2607591 ELISA Kit recognizes Guinea Pig AKAP13. It is sometimes possible for the material contained within the vial of "A-kinase anchor protein 13, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...