Chemical Structure
TRV130 agonist
TRV130 (Oliceridine)
Purity
>98%
Synonyms
TRV130; TRV130 (Oliceridine); TRV 130; TRV-130; TRV130 agonist
Purity/Purification
>98%
Solubility
DMSO
Formula
C22H31ClN2O2S
SMILES
COC1=C (SC=C1)CNCC[C@]2 (CCOC3 (C2)CCCC3)C4=CC=CC=N4
CAS Number
1401028-24-7
Preparation and Storage
Store at -20 degree C for 3 years (powder form); at -20 degree C for 6 months (Solution base)
Chemical Structure
Chemical Structure
Related Product Information for TRV130 agonist
TRV130 is an opioid drug that is under evaluation in human clinical trials for the treatment of acute severe pain. TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less -arrestin 2 recruitment and receptor internalization, it displays less adverse effects than morphine.
Product Categories/Family for TRV130 agonist
References
Lakshmi Vasudevan,.et al. Assessment of Structure-Activity Relationships and Biased Agonism at the Mu Opioid Receptor of Novel Synthetic Opioids Using a Novel, Stable Bio-Assay Platform, Biochem Pharmacol, 2020, Mar 14;177:113910 PMID: 32179045
Yudin Y,.et al. The G protein-biased agents PZM21 and TRV130 are partial agonists ofu-opioid receptor-mediated signaling to ion channels, Br J Pharmacol, 2019, May 9 PMID: 31074038
Anna M. Gutridge,.et al. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder, Br J Pharmaco, 2019, 08 NovemberAraldi D,.et al. Mu-Opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat, Neuroscience, 2018, Dec 1; 394: 60-71 PMID: 30342200Yevgen Yudin,.et al. The G protein-biased PZM21 and TRV130 act as partial agonists ofu-opioid receptors signaling to ion channel targets, bioRxiv, 2018, 2018 Luma
Yudin Y,.et al. The G protein-biased agents PZM21 and TRV130 are partial agonists ofu-opioid receptor-mediated signaling to ion channels, Br J Pharmacol, 2019, May 9 PMID: 31074038
Anna M. Gutridge,.et al. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder, Br J Pharmaco, 2019, 08 NovemberAraldi D,.et al. Mu-Opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat, Neuroscience, 2018, Dec 1; 394: 60-71 PMID: 30342200Yevgen Yudin,.et al. The G protein-biased PZM21 and TRV130 act as partial agonists ofu-opioid receptors signaling to ion channel targets, bioRxiv, 2018, 2018 Luma
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Product Notes
The TRV130 (Catalog #AAA3840309) is an Agonist and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TRV130, Agonist" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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