Proteasomal ubiquitin receptor ADRM1 (ADRM1) Recombinant Protein | ADRM1 recombinant protein
Recombinant Human Proteasomal ubiquitin receptor ADRM1 (ADRM1)
Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.
Protein type: Cell development/differentiation; Proteasome complex
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: cytosol; integral to plasma membrane; membrane; nucleoplasm; plasma membrane; proteasome complex
Molecular Function: protease binding; protein binding; ubiquitin binding
Biological Process: proteasome assembly; protein deubiquitination; RNA elongation from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process