Adhesion Regulating Molecule 1 Recombinant Protein | ADRM1 recombinant protein

Recombinant Human Adhesion Regulating Molecule 1

Cat. Num. AAA144655

• Gene Names: ADRM1; ARM1; ARM-1; GP110
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Adhesion Regulating Molecule 1; Recombinant Human Adhesion Regulating Molecule 1; ADRM1 Human; Adhesion Regulating Molecule 1 Human Recombinant; Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Proteasome regulatory particle non-ATPase 13; hRpn13; Rpn13 homolog; ADRM1; ARM1; Rpn13; ADRM1 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: ADRM1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMTTSGA LFPSLVPGSR GASNKYLVEF RAGKMSLKGT TVTPDKRKGL VYIQQTDDSL IHFCWKDRTS GNVEDDLIIF PDDCEFKRVP QCPSGRVYVL KFKAGSKRLF FWMQEPKTDQ DEEHCRKVNE YLNNPPMPGA LGASGSSGHE LSALGGEGGL QSLLGNMSHS QLMQLIGPAG LGGLGGLGAL TGPGLASLLG SSGPPGSSSS SSSRSQSAAV TPSSTTSSTR ATPAPSAPAA ASATSPSPAP SSGNGASTAA SPTQPIQLSD LQSILATMNV PAGPAGGQQV DLASVLTPEI MAPILANADV QERLLPYLPS GESLPQTADE IQNTLTSPQF QQALGMFSAA LASGQLGPLM CQFGLPAEAV EAANKGDVEA FAKAMQNNAK PEQKEGDTKD KKDEEEDMSL D.
• Sequence Length: 368

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for ADRM1 recombinant protein

Description: ADRM1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 431 amino acids (1-407 a.a) and having a molecular mass of 44.7kDa.ADRM1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Proteasomal ubiquitin receptor ADRM1 (ADRM1) functions as a proteasomal ubiquitin receptor. ADRM1 is an integral plasma membrane protein which promotes cell adhesion. ADRM1 is assumed to undergo O-linked glycosylation. ADRM1 gene expression is induced by gamma interferon in some cancer cells. ADRM1 employs the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.

Product Categories/Family for ADRM1 recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 527122034
• NCBI GeneID: 11047
• NCBI Accession #: NP_001268366.1
• NCBI GenBank Nucleotide #: NM_001281437.1
• UniProt Accession #: Q16186; Q96FJ7; Q9H1P2; A0PKB1
• Molecular Weight: 42,153 Da
• NCBI Official Full Name: proteasomal ubiquitin receptor ADRM1 isoform 2
• NCBI Official Synonym Full Names: adhesion regulating molecule 1
• NCBI Official Symbol: ADRM1
• NCBI Official Synonym Symbols: ARM1; ARM-1; GP110
• NCBI Protein Information: proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory particle non-ATPase 13; rpn13 homolog
• UniProt Protein Name: Proteasomal ubiquitin receptor ADRM1
• UniProt Gene Name: ADRM1
• UniProt Synonym Gene Names: GP110; Gp110; ARM-1; hRpn13
• UniProt Entry Name: ADRM1_HUMAN

NCBI Description

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family.

Protein type: Cell development/differentiation; Proteasome complex

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: nucleoplasm; proteasome complex; membrane; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; protease binding

Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly