Typical Testing Data/Standard Curve (for reference only)
Rat Adiponectin ELISA Kit | ADIPOQ elisa kit
Rat Adiponectin PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Background/Introduction: Adiponectin (ADPN) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. Adiponectin is a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. It is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions. Adiponectin is mapped to 3q27 and can protect the organism from systemic inflammation by promoting the clearance of early apoptotic cells by macrophages through a receptor-dependent pathway involving calreticulin.
NCBI and Uniprot Product Information
NCBI Description
adipocyte complement-related factor that plays a role in obesity-related insulin resistance [RGD, Feb 2006]
Uniprot Description
adiponectin: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex). Synthesized exclusively by adipocytes and secreted into plasma.
Protein type: Hormone; Secreted, signal peptide; Secreted; Endoplasmic reticulum
Cellular Component: extracellular space; collagen; cell surface; protein complex; endoplasmic reticulum; perinuclear region of cytoplasm
Molecular Function: identical protein binding; protein homodimerization activity; hormone activity; sialic acid binding; receptor binding
Biological Process: circadian rhythm; negative regulation of MAP kinase activity; response to glucocorticoid stimulus; glucose homeostasis; positive regulation of glucose import; negative regulation of gluconeogenesis; response to glucose stimulus; adiponectin-mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; negative regulation of blood pressure; response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of signal transduction; glucose metabolic process; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of fat cell differentiation; membrane depolarization; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; cellular response to insulin stimulus; brown fat cell differentiation; fatty acid oxidation; response to activity; negative regulation of transcription, DNA-dependent; positive regulation of myeloid cell apoptosis; positive regulation of blood pressure; negative regulation of phagocytosis; negative regulation of smooth muscle cell proliferation; negative regulation of hormone secretion; membrane hyperpolarization; positive regulation of cellular protein metabolic process; negative regulation of smooth muscle cell migration; negative regulation of granulocyte differentiation; positive regulation of interleukin-8 production; negative regulation of cell migration; protein homooligomerization; response to nutrient; response to nutrient levels; negative regulation of heterotypic cell-cell adhesion; negative regulation of tumor necrosis factor production; negative regulation of synaptic transmission; response to sucrose stimulus; positive regulation of fatty acid metabolic process; fatty acid beta-oxidation; negative regulation of low-density lipoprotein receptor biosynthetic process; negative regulation of macrophage differentiation; positive regulation of protein kinase activity; negative regulation of inflammatory response; response to hypoxia; positive regulation of protein amino acid phosphorylation
Research Articles on ADIPOQ
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Product Notes
The Rat ADIPOQ adipoq (Catalog #AAA177263) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA177263 ELISA Kit recognizes Rat ADIPOQ. It is sometimes possible for the material contained within the vial of "Adiponectin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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