Mouse Pituitary adenylate cyclase-activating polypeptide ELISA Kit | Adcyap1 elisa kit
Mouse Pituitary adenylate cyclase-activating polypeptide ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Uniprot Description
ADCYAP1: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Belongs to the glucagon family.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular region; extracellular space; intracellular; terminal button
Molecular Function: hormone activity; neuropeptide hormone activity; peptide hormone receptor binding; pituitary adenylate cyclase activating polypeptide activity; pituitary adenylate cyclase-activating peptide receptor binding; receptor binding; receptor signaling protein activity
Biological Process: adenylate cyclase activation; ATP metabolic process; behavioral fear response; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; histamine secretion; negative regulation of acute inflammatory response to antigenic stimulus; negative regulation of acute inflammatory response to non-antigenic stimulus; negative regulation of cell cycle; negative regulation of potassium ion transport; nervous system development; neurite development; neuropeptide signaling pathway; ovarian follicle development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of growth hormone secretion; positive regulation of GTPase activity; positive regulation of interleukin-6 production; positive regulation of protein kinase activity; positive regulation of synaptic transmission, glutamatergic; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; regulation of G-protein coupled receptor protein signaling pathway; regulation of postsynaptic membrane potential; regulation of protein localization; sensory perception of pain
Research Articles on Adcyap1
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Product Notes
The Mouse Adcyap1 adcyap1 (Catalog #AAA289963) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA289963 ELISA Kit recognizes Mouse Adcyap1. It is sometimes possible for the material contained within the vial of "Pituitary adenylate cyclase-activating polypeptide, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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