Cat Adenylate Cyclase 10, Soluble ELISA Kit | ADCY10 elisa kit

Cat Adenylate Cyclase 10, Soluble ELISA Kit

• Gene Names: ADCY10; SAC; HCA2; SACI; Sacy; hsAC
• Reactivity: Cat
• Synonyms: Adenylate Cyclase 10; Soluble; Cat Adenylate Cyclase 10; Soluble ELISA Kit; ADCY10 elisa kit

• Reactivity: Cat
• Sequence Length: 1610

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 209976994
• NCBI GeneID: 55811
• NCBI Accession #: NP_060887.2
• NCBI GenBank Nucleotide #: NM_018417.5
• UniProt Accession #: Q96PN6; O95558; Q5R329; Q5R330; Q8WXV4; Q9NNX0; B4DZF0; F5GWS5
• Molecular Weight: 187,149 Da
• NCBI Official Full Name: adenylate cyclase type 10 isoform 1
• NCBI Official Synonym Full Names: adenylate cyclase 10 (soluble)
• NCBI Official Symbol: ADCY10
• NCBI Official Synonym Symbols: SAC; HCA2; SACI; Sacy; hsAC
• NCBI Protein Information: adenylate cyclase type 10; AH-related protein; ATP pyrophosphate-lyase; 3',5'-cyclic AMP synthetase; germ cell soluble adenylyl cyclase; testicular soluble adenylyl cyclase (SAC)
• UniProt Protein Name: Adenylate cyclase type 10
• Protein Family: Adenylate cyclase
• UniProt Gene Name: ADCY10
• UniProt Synonym Gene Names: SAC; hsAC; sAC
• UniProt Entry Name: ADCYA_HUMAN

NCBI Description

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

Uniprot Description

SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lyase; Adenylyl cyclase; Nucleotide Metabolism - purine; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: growth cone; cytoskeleton; cell soma; apical part of cell; perinuclear region of cytoplasm; axon; cytoplasm; dendrite; plasma membrane; cytosol

Molecular Function: manganese ion binding; magnesium ion binding; ATPase binding; ATP binding; adenylate cyclase activity

Biological Process: positive regulation of apoptosis; spermatogenesis; cAMP biosynthetic process

Disease: Hypercalciuria, Absorptive, 2