Typical Testing Data/Standard Curve (for reference only)
Rat Disintegrin and metalloproteinase domain-containing protein 17 ELISA Kit | Adam17 elisa kit
Rat Disintegrin and metalloproteinase domain-containing protein 17 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
expression occurs in response to oxygen glucose deprivation, may play a role in inhibition of apoptosis via induction of TNF-alpha release [RGD, Feb 2006]
Uniprot Description
TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.86; Protease; Membrane protein, integral
Cellular Component: actin cytoskeleton; apical plasma membrane; cell surface; cytoplasm; focal adhesion; integral to membrane; integral to plasma membrane; intercellular junction; lipid raft; membrane; plasma membrane
Molecular Function: integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metallopeptidase activity; Notch binding; PDZ domain binding; SH3 domain binding; zinc ion binding
Biological Process: B cell differentiation; cell adhesion; cell adhesion mediated by integrin; cell motility involved in cell locomotion; defense response to Gram-positive bacterium; epidermal growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germinal center formation; integrin-mediated signaling pathway; membrane protein ectodomain proteolysis; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; Notch signaling pathway; PMA-inducible membrane protein ectodomain proteolysis; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of protein amino acid phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; production of molecular mediator of acute inflammatory response; proteolysis; regulation of mast cell apoptosis; response to drug; response to high density lipoprotein stimulus; response to hypoxia; response to lipopolysaccharide; spleen development; T cell differentiation in the thymus; wound healing, spreading of epidermal cells
Research Articles on Adam17
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Product Notes
The Rat Adam17 adam17 (Catalog #AAA2883392) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2883392 ELISA Kit recognizes Rat Adam17. It is sometimes possible for the material contained within the vial of "Disintegrin and metalloproteinase domain-containing protein 17, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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