Disintegrin and metalloproteinase domain-containing protein 15 Recombinant Protein | Adam15 recombinant protein
Disintegrin and metalloproteinase domain-containing protein 15
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
Uniprot Description
ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.4.24.-; Cell adhesion; Protease
Cellular Component: cell surface
Molecular Function: integrin binding; metallopeptidase activity; protein binding; SH3 domain binding
Biological Process: innate immune response; integrin-mediated signaling pathway; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell-matrix adhesion
Research Articles on Adam15
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Product Notes
The Adam15 adam15 (Catalog #AAA7042082) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 208-864aa; full length protein. The amino acid sequence is listed below: DVVTETKIVE LVIVADNSEV RKYPDFQQLL NRTLEAALLL DTFFQPLNVR VALVGLEAWT QHNLIEMSSN PAVLLDNFLR WRRTDLLPRL PHDSAQLVTV TSFSGPMVGM AIQNSICSPD FSGGVNMDHS TSILGVASSI AHELGHSLGL DHDSPGHSCP CPGPAPAKSC IMEASTDFLP GLNFSNCSRQ ALEKALLEGM GSCLFERQPS LAPMSSLCGN MFVDPGEQCD CGFPDECTDP CCDHFTCQLR PGAQCASDGP CCQNCKLHPA GWLCRPPTDD CDLPEFCPGD SSQCPSDIRL GDGEPCASGE AVCMHGRCAS YARQCQSLWG PGAQPAAPLC LQTANTRGNA FGSCGRSPGG SYMPCAPRDV MCGQLQCQWG RSQPLLGSVQ DRLSEVLEAN GTQLNCSWVD LDLGNDVAQP LLALPGTACG PGLVCIGHRC QPVDLLGAQE CRRKCHGHGV CDSSGHCRCE EGWAPPDCMT QLKATSSLTT GLLLSLLLLL VLVLLGASYW HRARLHQRLC QLKGSSCQYR APQSCPPERP GPPQRAQQMT GTKQASVVSF PVPPSRPLPP NPVPKKLQAA LADRSNPPTR PLPADPVVRR PKSQGPTKPP PPRKPLPANP QGQHPPGDLP GPGDGSLPLV VPSRPAPPPP AASSLYL. It is sometimes possible for the material contained within the vial of "Disintegrin and metalloproteinase domain-containing protein 15, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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